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Chemotherapy has been a major option in clinic treatment of malignant tumors. However, single chemotherapy faces some drawbacks, such as multidrug resistance, severe side effects, which hinder its clinic application in tumor treatment. Multifunctional nanoparticles loading with chemotherapeutic agent and photosensitizer could be a promising way to efficiently conduct tumor combination therapy. In the current study, a novel pH-sensitive and bubble-generating mesoporous silica-based drug delivery system (denoted as M(a)D@PI-PEG-RGD) was constructed. Ammonium bicarbonate (NH
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In recent years, mesoporous silica nanoparticles (MSNs) have been widely used in the construction of various intelligent drug delivery systems due to their unique and excellent properties. The stimuli-responsive drug delivery system based on mesoporous silica nanoparticles can effectively load anticancer drugs and target them to tumor cells, and then responsively release anticancer drugs under the action of specific stimulation signals. The method of specifically delivering anticancer drugs to target sites not only can greatly improvethe drug efficacy, but also effectively reduce the side effects of anticancer drugs on normal tissues and organs. Thereby the advantages of anticancer drugs in tumor therapy are improved. In this paper, the applications and developments of stimuliresponsive mesoporous silica nano drug delivery systems in tumor therapy were summarized.
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Malignant tumors are the second most important cause of death after cardiovascular and cerebrovascular diseases. Chemotherapeutic drugs for tumor treatment have strong toxic side effects. The common solution is to use nanoparticle as a carrier that can deliver drugs to tumor issues so as to kill the tumor cells. However, most of the current drug-carriers have a serious drug loss before reaching the tumor area, which makes the difficult control of drug release. Multi-stimulus responsive nano-carrier systems can overcome these drawbacks and make drug release controllable. pH/redox dual sensitive nano-carrier systems are currently hot research direction. In this paper, the research progress of pH/redox dual sensitive nano-carrier systems in recent years was reviewed in order to provide reference for relative researches.
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Breast cancer is one of the most common cancers.The clinical treatment of breast cancer has made great progress,but the inherent or acquired drug resistance,tumor migration and tumor infiltration,which lead to poor treatment efficiency and eventually death,are still the urgent problems to be solved.As with the occurrence and development of common tumors,the abnormal proliferation,migration and infiltration of breast tumor cells and muhidrug resistance (MDR) are closely related to the abnormal expression of specific genes in the cell.At present,many studies have found that the occurrence and development of tumor is closely related to the abnormal expression of microRNA.Therefore,in order to better understand the molecular mechanism of the occurrence and development of breast cancer,it is necessary to study the function of microRNA in breast tumor cells.In this paper,the application of microRNA in the treatment of breast cancer was reviewed,striving for providing effective ideas for the future selection of new strategies to control the development of tumors.
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Objective To establish a high performance liquid chromatography (HPLC) method for the determination of baicalin and naringin inQinbei mixture.Methods The HPLC system consisted of the Fortis-C18(4.6 mm × 250 mm, 5μm) column, and the mobile phase consisted of MeOH:0.4% H3PO4 (42:58), and the flow rate was 1.0 ml/min, and the UV detector was set at 280 nm, and the column temperature was 30℃.Results The linear response range of baicalin was 0.062-0.930μg. The linear response range of naringin was 0.033-0.492μg. The average recovery of baicalin was 98.11% (RSD=1.62%). The average recovery of naringin was 96.78% (RSD=1.74%).Conclusions The method is simple, rapid, accurate and repeatable. It can be applied in determination of baicalin and naringin inQinbei mixture.
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In recent years,the incidence of malignant tumors continually increased with the trend of younger age in onset age,which pose a serious threat to human health.At present,there are a variety of clinical anti-tumor treatments.However,a single treatment usually cannot achieve the best therapeutic effect.As a result,the combination therapy is often used in clinical practice.Combination therapy not only can enhance the therapeutic effect and reduce the toxic side effects of drugs,but also can alleviate the pain of patients.Chemotherapy is a commonly used clinical treatment for tumors.However,it can lead to greater side-effects,and cause irreversible damage to normal cells while killing the tumor cells.Photodynamic therapy uses the specific wavelengths of light to excite and activate the photosensitizer enriched in the tumor local.As a result,the tumor cells are killed directly or indirectly by photodynamic reactions with the participation of internal oxygen.Tumorassociated antigen will appear following the chemotherapy or photodynamic therapy.The immune system will stimulate the body to produce specific anti-tumor immune response after identifying the tumor-associated antigens.The combination treatment of chemotherapy and photodynamic therapy combined with immunotherapy not only can effectively improve the treatment effect of chemotherapy drugs and reduce drug side effects,inhibit tumor metastasis,but also can induce the production long-term anti-tumor immune response,so as to maximize the treatment effect.In this paper,the progress of the researches on chemotherapy,photodynamic therapy and immunotherapy in recent years were summarized.
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In recent years,the incidence of malignant tumors continually increased with the trend of younger age in onset age,which pose a serious threat to human health.At present,there are a variety of clinical anti-tumor treatments.However,a single treatment usually cannot achieve the best therapeutic effect.As a result,the combination therapy is often used in clinical practice.Combination therapy not only can enhance the therapeutic effect and reduce the toxic side effects of drugs,but also can alleviate the pain of patients.Chemotherapy is a commonly used clinical treatment for tumors.However,it can lead to greater side-effects,and cause irreversible damage to normal cells while killing the tumor cells.Photodynamic therapy uses the specific wavelengths of light to excite and activate the photosensitizer enriched in the tumor local.As a result,the tumor cells are killed directly or indirectly by photodynamic reactions with the participation of internal oxygen.Tumorassociated antigen will appear following the chemotherapy or photodynamic therapy.The immune system will stimulate the body to produce specific anti-tumor immune response after identifying the tumor-associated antigens.The combination treatment of chemotherapy and photodynamic therapy combined with immunotherapy not only can effectively improve the treatment effect of chemotherapy drugs and reduce drug side effects,inhibit tumor metastasis,but also can induce the production long-term anti-tumor immune response,so as to maximize the treatment effect.In this paper,the progress of the researches on chemotherapy,photodynamic therapy and immunotherapy in recent years were summarized.
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Objective To develop paclitaxel-loaded polymeric micelles from poly (ε-caprolactone)-poly (ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL),and to evaluate in vitro cytotoxicity as well as in vivo antitumor activity against EMT-6 tumor breast cell.Methods Paclitaxel-loaded polymeric micelles were prepared by thin-film hydration and ultrasonic method.The physical status of paclitaxel inside the polymeric micelles was investigated by differential scanning calorimetry (DSC).In vitro cytotoxicity of paclitaxel-loaded polymeric micelles against EMT-6 cell line was assessed by MTT assay.In vivo anticancer activity was evaluated against EMT-6 tumorbearing mice,with commercially available Taxol injection as control.Results Paclitaxel-loaded polymeric micelles exhibited homogeneous spherical shapes with apparent core-shell morphology.The average diameter of paclitaxelloaded polymeric micelles was 93 nm.DSC study indicated that paclitaxel was in solid amorphous state after being encapsulated in the polymeric micelles.In vitro cytotoxicity demonstrated that the cytotoxic effect of paclitaxelloaded polymeric micelles was lower than that of Taxol injection at the same paclitaxel content.Paclitaxel-loaded polymeric micelles showed greater tumor growth-inhibition effect in vivo on EMT-6 breast tumor in comparison with that of Taxol injection,with tumor growth inhibition of 85.79％ and 63.37％,respectively (P＜0.05).Conculsions The prepared paclitaxel-loaded polymeric micelles showed high anti-tumoral efficacy and low toxicity,and might have the potential to be developed as an effective anticancer drug-delivery system for cancer chemotherapy.
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Polymersomes have attracted tremendous attention as novel drug delivery systems because of their unique and superior structure,tunable membrane properties,colloidal stability,and ability in encapsulating a broad range of both water soluble and insoluble substances.In this paper,preparation method and criteria for the formation of polymersomes,their structure and characterization as well as amphiphilic block copolymers for vesicle formation are addressed.Moreover,research progress on polymersomes as drug delivery system in the field of therapeutic and diagnostic applications are reviewed in this paper.
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ZHANG Lin-hua, GAO Rui-chang, XU Ming-li (School of Chemical Engineering, Tianjin University, Tianjin 300072, China)